Ultrasonographic and radionuclide detection of hepatocellular carcinoma in cirrhotics with low alpha-fetoprotein levels

Maringhini A, Cottone M, Sciarrino E, Marcenò MP, La Seta F, Rinaldi F, Pagliaro L.
Cancer. 1984 Dec 15;54(12):2924-6.PMID: 6208995

Abstract

A total of 67 cirrhotic patients with clinically suspected neoplastic degeneration and low alpha-fetoprotein levels were assessed prospectively with ultrasound and gold (198Au) scintigraphy. Ultrasound showed space-occupying lesions in 22 of the 24 patients who had a final diagnosis of hepatocellular carcinoma (HCC) (sensitivity, 95.8%) and excluded the presence of HCC in 37 of the 43 patients with cirrhosis only (specificity, 86.0%; efficiency, 90.8%). Scintigraphy demonstrated a cold defect in 22 of the 24 patients who had a final diagnosis of HCC (sensitivity, 95.8%) and excluded the presence of HCC in 22 of the 43 patients with cirrhosis only (specificity, 51.1%; efficiency, 69.8%). It was concluded that the most accurate screening plain in cirrhotic patients suspected of having HCC with alpha-fetoprotein values below 500 ng/ml would consist of ultrasonography followed, as clinically indicated, by ultrasonographic or laparoscopic guided biopsy.

Link PubMed


Altre pubblicazioni

INFO
immagine_profilo
Alberto Maringhini
Direttore Medicina Interna 1
ARNAS Civico
Research gate score
  • Research Interests: 996.7
  • Citations: 1.973
  • h-index: 26
ATTIVITÀ DI RICERCA IN CORSO
Screening del cancro del pancreas: un trial controllato
Coordinatori dello studio
  • Dott. Alberto Maringhini
  • Dott.ssa Rosalia Patti
  • Dott.ssa Anna Riili
  • Dott.ssa Margherita Rossi
Scopo dello studio

dimostrare che lo screening di una popolazione a rischio per cancro del pancreas permette:

  • diagnosi precoce
  • migliore sopravvivenza
Links
CONTATTI

E-Mail:
alber.ghini55@gmail.com

Contatto telefonico per visite intramoenia:
091229798

Indirizzo:
P.Za Leotta Nicola, 4, 90127 Palermo PA

SCRIVI UN MESSAGGIO

    Condividi su